Protease Inhibitors and Phosphatase Inhibitors
Apexbio Technology LLC Gliotoxin 67-99-2 5mg
Gliotoxin (CAS 67-99-2) is a small-molecule inhibitor targeting the chymotrypsin-like activity of the 20S proteasome farnesyltransferase (IC50 80 M) and geranylgeranyltransferase I (IC50 17 M) It modulates protein prenylation pathways and proteasomal function thereby regulating processes involved in tumor cell proliferation and immune cell functionality Gliotoxin exerts its biological activity primarily through inhibition of these enzymes and by modulating host-pathogen interactions including suppression of macrophage phagocytic function and facilitating Aspergillus internalization in lung epithelial (A549) cells via activation of host phospholipase D In vitro studies demonstrate growth inhibition of human breast cancer cells Based on these pharmacological properties gliotoxin holds research potential in cancer biology proteasome function fungal pathogen-host cell interaction and cellular signaling pathway studies
Medchemexpress LLC N1-(5-chloro-4-(5-(cyclopropylmethyl)-1-methyl-1H-pyrazol-4-yl)pyrimidin-2-yl)cyclohexane-1,4-diamine | 2079068-74-7 | 98.6% | 360.88 g·mol⁻¹ | C18H25ClN6 | 10MG
BTX-A51 is a potent, orally active small-molecule inhibitor of casein kinase 1α (CK1α) with reported anti-leukemic activity; it induces leukemia cell apoptosis and is used as a research reagent in biochemical and cellular studies.
- Potent inhibitor of casein kinase 1α (CK1α).
- Orally active small-molecule suitable for in vivo and in vitro studies.
- Reported to induce leukemia cell apoptosis and demonstrate anti-leukemic activity.
- High purity, typically 98.58% as supplied.
- Solid form, white to light yellow appearance.
- Defined chemical identity: C18H25ClN6, MW 360.88 g·mol⁻¹.
- Available in small research pack sizes including 10 mg.
Bioworld Protease Inhibitor Cocktail III (Animal Free for Mammalian Cells), 1 Vial(s)
Mixture of six protease inhibitors for use in applications that require animal free reagents. Supplied in 1ml DMSO. Will treat proteases extracted from 20g tissue.Contains:100 mM AEBSF 80 μM Aprotinin, recombinant (animal free)5 mM Bestatin1.5 mME-642 mM LeupeptinHemisulfate1 mM Pepstatin ASpecificity: Serine Proteases, Cyteine Proteases Trypsin like Proteases, Aspartic Proteases as well as AminopeptidasesThis product is sold for research use only.
Bioworld Protease Inhibitor Cocktail III (for Mammalian Cells), 1 mL
Mixture of six protease inhibitors for use with mammalian cells and tissue extracts. Supplied in l ml DMSO. Will treat proteases extracted from 20g tissue.* Contains: AEBSF, E-64, Aprotinin, Leupeptin, Bestatin, Pepstatin A* Specificity: Serine Proteases, Cysteine Proteases, Trypsin like Proteases, Aspartic Proteases, AminopeptidasesUsually ships within 24 hours.This product is sold for laboratory research use only.
Apexbio Technology LLC PRO INHIB COCKT EDTA-FREE 1ML
PRO INHIB COCKT EDTA-FREE 1ML APEXBIO TECHNOLOGIES
Research Products International Corp Pepstatin A, 10 Milligrams
An inhibitor of aspartic proteases. Forms a 1:1 complex with proteases such as pepsin, renin and cathepsin D. Highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases.
Selleck Chemical LLC BIX 02189 5mg 1094614-85-3
BIX02189 is a selective inhibitor of MEK5 with IC50 of 1.5 nM, also inhibits ERK5 catalytic activity with IC50 of 59 nM in cell-free assays, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
![Medchemexpress LLC 2-Pyrazinecarboxamide, 6-ethyl-5-[(trans-4-methoxycyclohexyl)amino]-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]- | 1373409-08-5 | 98.0% | 580.76 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000437704-Logo.png-250.jpg){kind=logo}
Medchemexpress LLC 2-Pyrazinecarboxamide, 6-ethyl-5-[(trans-4-methoxycyclohexyl)amino]-3-[[3-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]- | 1373409-08-5 | 98.0% | 580.76 | 50 MG
EML4-ALK kinase inhibitor 1 is a potent, orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK), with an IC50 of 1 nM. It is for research use only and not sold to patients.
- Potent orally active inhibitor of EML4-ALK with an IC50 of 1 nM.
- Available in various sizes, including free samples.
- Provided with detailed solubility and storage information for both in vitro and in vivo applications.
Cayman Chemical COXhumn InhIbItr ScreenI 96Wel
The COX (human) Inhibitor Screening Assay directly measures PGF2α by stannous chloride reduction of COX-derived PGH2 produced in the COX reaction. The prostanoid product is quantified via ELISA using an antiserum specific to PGF2a. This assay includes recombinant human COX-1 and COX-2 and is an excellent tool for general COX-1 and COX-2 inhibitor screening. It will also help to eliminate false positive leads generated by less specific methods.
Crescent Chemical Co Inc PEFABLOC SC
PEFABLOC SC Protease inhibitor with major advantages over other inhibitors: Excellent stability at neutral pH. Ready solubility in aqueous buffers; LD50 (oral) 2800 mg/kg. Broad specificity for serine proteases. Minimum effect on cell growth. Size - 500
Apexbio Technology LLC Cell-permeable, irreversible cysteine protease inhibitor 88321-09-9. MFCD00132883
Cell-permeable, irreversible cysteine protease inhibitor 88321-09-9. MFCD00132883
Selleck Chemical LLC PP2 5mg 172889-27-9 AG 1879,AGL 1879
PP2 (AG 1879, AGL 1879), a Src family kinase inhibitor, potently inhibits Lck/Fyn with IC50 of 4 nM/5 nM in cell-free assays, ~100-fold less potent to EGFR, inactive for ZAP-70, JAK2 and PKA. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Enzo Life Sciences RK-682 (1mg). CAS: 154639-24-4
RK-682 is a novel tyrosine phosphatase inhibitor isolated from Streptomyces sp. It inhibits the dual specificity VHR phosphatase (IC50=2.0µM) selectively over CD45 (IC50=54µM), Cdc25B and PTP1B (IC50~42µM). RK-682 inhibits cell cycle progression of Ball-1 cells at the G1/S transition and enhances ATP-induced long-term potentiation in guinea pig hippocampal CA1 neurons. Shows potent activity against HIV-1 protease. Purity: ≥98% (HPLC). Solubility: Soluble in DMSO (25mg/ml), 100% ethanol (10mg/ml), methanol or dimethyl formamide. Long Term Storage: -20°C.
Selleck Chemical LLC PMSF 10mM/1mL 329-98-6 Phenylmethylsulfonyl Fluoride
PMSF (Phenylmethylsulfonyl Fluoride) is an irreversible serine/cysteine protease inhibitor. *For Research & Development use only. Product is not intended for drug, household, or human consumption.